ZOLEDRONATE UPREGULATES MMP-9 AND -13 IN RAT VASCULAR SMOOTH MUSCLE CELLS BY INDUCING OXIDATIVE STRESS

Mehmet Zuhuri Arun,1 Buket Reel,1 Graciela B Sala-Newby,2 Mark Bond,2 Aikaterini Tsaousi,2 Perry Maskell,2 Andrew C Newby21Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkey; 2Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK Background: Bisphosphonates, including zoledronate, target os

Variational methods for image registration basically involve a regularizer to ensure that the resulting well-posed problem admits a solution.Different choices of regularizers lead Charcoal to different deformations.On one hand, the conventional regularizers, such as the elastic, diffusion and curvature regularizers, are able to generate globally sm